Ineligible? What does that mean?
StemCyte follows over 400+ Standard Operation Procedures (SOPs) to process and store the unit as transplant ready. However, after performing a medical evaluation on the patient, an accredited transplant physician can find a unit not suitable or desirable for a transplant. This could be a unit with low collected volume, low total nucleated cell (TNC), congenital diseases, sterility, etc.
What exactly are these situations? And how does StemCyte Care make a difference in situations like these?
Expectant parents decide to bank their newborn’s stem cells because they want to protect the family’s future and long-term health.
Banking the newborn’s stem cells is only the first step toward that goal, which means the family is far from being 100% covered.
Since the transplant physician is the one who makes the final decision on whether a cord blood unit is eligible for transplant, it is crucial to ensure a back-up plan is in place if the outcome is not in your favor.
The following situations might affect the eligibility of a cord blood unit:
Low collected volume / low total nucleated cells (TNC)
According to the information published on Parents Guide to Cord Blood, for treating cancer, the transplant dose should be at least 25 million TNC per kilogram of patient body weight*.
The average cord blood collection holds 8.6 million TNC per mL. Thus, the optimal transplant dose requires harvesting:
- 1.3 mL of cord blood for every pound of patient weight, -or-
- 2.9 mL of cord blood for every kg of patient weight.
The more you weigh, the more cells needed.
Reed, W et al., Blood 2003;101(1):351 doi:10.1182/blood-2002-02-0394Barker, JN et al., Blood 2005;105:1343-1347 doi:10.1182/blood-2004-07-2717
Eapen, M et al. Lancet 2007;369:1947-54 doi:10.1016/S0140-6736(07)60915-5
Rocha & Gluckman Brit. J. Haematology 2009;147(2):262-274 doi:10.1111/j.1365-2141.2009.07883.x
Congenital disease refers to a condition or disease which is present at or shortly after birth. Once a child is confirmed with congenital disease, use of his/her own cord blood unit is contraindicated because the defect is of a genetic origin. For example, it can’t treat malignant cancer, such as congenital leukemia, because the genetic mutation for cancer already exists in the DNA.
A unit can get contaminated before it reaches the processing lab. Currently, StemCyte continues to store the unit for use and it may still be released for transplant with permission from the transplant physician. However, it will not be released for a clinical trial studying new applications for cord blood use. Clinical trials require sterile units in order to decrease variable factors in the study.
HOW TO MINIMIZE CONTAMINATION AT COLLECTION? (Usually collected by the doctor or midwife.)
- Wipe the cord using sterile gauze.
- Using the ChloraPrep applicator – scrub the full width of the cord on both sides of the intended venipuncture site for approximately 2 minutes. Let the ChloraPrep dry for approximately 1 minute before performing the venipuncture.
What if I still decide not to purchase StemCyte Care? Are there any alternative options if any of the above scenarios happen?
Purchasing StemCyte Care is optional. Yes, there are alternative options.
Option 1 - Sibling
The first option is to look for sibling cord blood units. Considering a 75% match between sibling donors, using a sibling unit is definitely preferable under the condition that the sibling unit does not have any of the mentioned conditions present (congenital diseases, low volume/TNC, sterility, etc.)
Option 2 - Public Donation
The second option is to find a suitable unit in a public donor bank. Currently, the cost of a public donated unit is somewhere between $35,000 - $40,000.
An accredited transplant physician holds the final call on the usage of one’s own cord blood unit. StemCyte has you covered if the physician deems the unit as ineligible due to the above situations.
StemCyte is a hybrid bank, which offers both public and private cord blood banking service, and that’s why StemCyte is the only bank that has the ability to offer this one of a kind service to all.
When comparing both options, StemCyte Care without a doubt will bring the greatest value to your family when it comes to cost or protection. Your family and you can be assured that StemCyte will be there with you every step of the way!
If your child's cord blood stem cells become ineligible for transplant, StemCyte will*: